Artificial sweeteners screw up appetite. Artificial sweeteners disrupt your body's ability to accurately guage your caloric intake and regulate your appetite accordingly.

Professor Terry Davidson and associate professor Susan Swithers, both in the Department of Psychological Sciences, found that artificial sweeteners may disrupt the body's natural ability to "count" calories based on foods' sweetness. This finding may explain why increasing numbers of people in the United States lack the natural ability to regulate food intake and body weight. The researchers also found that thick liquids aren't as satisfying – calorie for calorie – as are more solid foods.

Link [Boing Boing]

I gotta say- this rings true to my experience.

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